dc.identifier.uri |
http://dx.doi.org/10.15488/4731 |
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dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/4773 |
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dc.contributor.author |
Ringel, Michael T.
|
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dc.contributor.author |
Brüser, Thomas
|
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dc.date.accessioned |
2019-04-23T08:46:58Z |
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dc.date.available |
2019-04-23T08:46:58Z |
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dc.date.issued |
2018 |
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dc.identifier.citation |
Ringel, M.T.; Brüser, T.: The biosynthesis of pyoverdines. In: Microbial Cell 5 (2018), Nr. 10, S. 424-437. DOI: https://doi.org/10.15698/mic2018.10.649 |
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dc.description.abstract |
Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants. Prominent examples include pathogenic or non-pathogenic species such as Pseudomonas aeruginosa, P. putida, P. syringae, or P. fluorescens. Many distinct pyoverdines have been identified, all of which have a dihydroxyquinoline fluorophore in common, derived from oxidative cyclizations of non-ribosomal peptides. These serve as precursor of pyoverdines and are commonly known as ferribactins. Ferribactins of distinct species or even strains often differ in their sequence, resulting in a large variety of pyoverdines. However, synthesis of all ferribactins begins with an L-Glu/D-Tyr/L-Dab sequence, and the fluorophore is generated from the D-Tyr/L-Dab residues. In addition, the initial L-Glu residue is modified to various acids and amides that are responsible for the range of distinguishable pyoverdines in individual strains. While ferribactin synthesis is a cytoplasmic process, the maturation to the fluorescent pyoverdine as well as the tailoring of the initial glutamate are exclusively periplasmic processes that have been a mystery until recently. Here we review the current knowledge of pyoverdine biosynthesis with a focus on the recent advancements regarding the periplasmic maturation and tailoring reactions. |
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dc.language.iso |
eng |
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dc.publisher |
Graz : Shared Science Publishers |
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dc.relation.ispartofseries |
Microbial Cell 5 (2018), Nr. 10 |
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dc.rights |
CC BY 4.0 Unported |
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dc.rights.uri |
https://creativecommons.org/licenses/by/4.0/ |
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dc.subject |
Pyoverdines |
eng |
dc.subject |
iron starvation |
eng |
dc.subject |
Pseudomonas fluorescens |
eng |
dc.subject |
Pseudomonas aeruginosa |
eng |
dc.subject |
non-ribosomal peptide synthetases |
eng |
dc.subject |
periplasmic tailoring |
eng |
dc.subject |
Microbiology |
eng |
dc.subject |
Cell biology |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
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dc.title |
The biosynthesis of pyoverdines |
eng |
dc.type |
Article |
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dc.type |
Text |
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dc.relation.issn |
2311-2638 |
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dc.relation.doi |
10.15698/mic2018.10.649 |
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dc.bibliographicCitation.firstPage |
424 |
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dc.bibliographicCitation.lastPage |
437 |
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dc.description.version |
publishedVersion |
ger |
tib.accessRights |
frei zug�nglich |
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