Juerjens, Gerrit; Kirschning, Andreas; Candito, David A.: Lessons from the Synthetic Chemist Nature. In: Natural Product Reports 32 (2015), Nr. 5, S. 723-737. DOI:
http://dx.doi.org/10.1039/c4np00160e
Zusammenfassung: |
This conceptual review examines the ideal multistep synthesis from the perspective of nature. We suggest that besides step- and redox economies, one other key to efficiency is steady state processing with intermediates that are immediately transformed to the next intermediate when formed. We discuss four of nature's strategies (multicatalysis, domino reactions, iteration and compartmentation) that commonly proceed via short-lived intermediates and show that these strategies are also part of the chemist's portfolio. We particularly focus on compartmentation which in nature is found microscopically within cells (organelles) and between cells and on a molecular level on multiprotein scaffolds (e.g. in polyketide synthases) and demonstrate how compartmentation is manifested in modern multistep flow synthesis.
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Lizenzbestimmungen: |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Publikationstyp: |
Article |
Publikationsstatus: |
publishedVersion |
Erstveröffentlichung: |
2015-03-02 |
Schlagwörter (englisch): |
asymmetric total-synthesis, one-pot preparation, organic-synthesis, isotactic polymethoxy-1-alkenes, enantioselective hydrogenation, polyketide synthases, product synthesis, ideal synthesis, step economy, biosynthesis
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Fachliche Zuordnung (DDC): |
540 | Chemie, 570 | Biowissenschaften, Biologie
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