dc.identifier.uri |
http://dx.doi.org/10.15488/15668 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/15789 |
|
dc.contributor.author |
Heinemann, Henrike
|
|
dc.contributor.author |
Becker, Kevin
|
|
dc.contributor.author |
Schrey, Hedda
|
|
dc.contributor.author |
Zeng, Haoxuan
|
|
dc.contributor.author |
Stadler, Marc
|
|
dc.contributor.author |
Cox, Russell J.
|
|
dc.date.accessioned |
2023-12-06T10:29:06Z |
|
dc.date.available |
2023-12-06T10:29:06Z |
|
dc.date.issued |
2023 |
|
dc.identifier.citation |
Heinemann, H.; Becker, K.; Schrey, H.; Zeng, H.; Stadler, M. et al.: Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa. In: RSC Advances 42 (2023), S. 29768-29772. DOI: https://doi.org/10.1039/D3RA06542A |
|
dc.description.abstract |
Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Cambridge : Royal Society of Chemistry |
|
dc.relation.ispartofseries |
RSC Advances 42 (2023) |
|
dc.rights |
CC BY 3.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by/3.0/ |
|
dc.subject |
heterologous production |
eng |
dc.subject |
macrolides |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa |
|
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.essn |
2046-2069 |
|
dc.relation.doi |
https://doi.org/10.1039/D3RA06542A |
|
dc.bibliographicCitation.volume |
42 |
|
dc.bibliographicCitation.firstPage |
29768 |
|
dc.bibliographicCitation.lastPage |
29772 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|