dc.identifier.uri |
http://dx.doi.org/10.15488/11507 |
|
dc.identifier.uri |
https://www.repo.uni-hannover.de/handle/123456789/11596 |
|
dc.contributor.author |
Kurz, Jennifer
|
eng |
dc.date.accessioned |
2021-11-11T13:14:26Z |
|
dc.date.available |
2021-11-11T13:14:26Z |
|
dc.date.issued |
2021 |
|
dc.identifier.citation |
Kurz, Jennifer: Transcriptional regulation of smooth muscle cell differentiation in the murine ureter. Hannover : Gottfried Wilhelm Leibniz Universität, Diss., 2021, vii, 189 S., viii-x, DOI: https://doi.org/10.15488/11507 |
eng |
dc.description.abstract |
Smooth muscle cell (SMC) differentiation in the murine ureter is regulated by a complex network of signaling pathways and transcription factors. In this work two zinc-finger transcription factors of the same family Gata2 and Gata6 and the Notch-signaling pathway were identified to be involved in this network. Investigation of mice with a conditional loss of Gata2, Gata6 and the unique mediator of Notch-signaling Rbpj revealed a delayed and reduced onset of SMC differentiation and peristaltic activity. Further analyses showed that Gata2, Gata6 and the Notch-signaling pathway regulate SMC differentiation by acting in different subprograms, but they all affect the activation of the master regulator of SMC differentiation myocardin (Myocd). |
eng |
dc.language.iso |
eng |
eng |
dc.publisher |
Hannover : Institutionelles Repositorium der Leibniz Universität Hannover |
|
dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. |
eng |
dc.subject |
ureter |
eng |
dc.subject |
smooth muscle cell differentiation |
eng |
dc.subject |
Gata6 |
eng |
dc.subject |
Gata2 |
eng |
dc.subject |
Notch signaling pathway |
eng |
dc.subject |
Ureter |
ger |
dc.subject |
Glattmuskeldifferenzierung |
ger |
dc.subject |
Gata6 |
ger |
dc.subject |
Gata2 |
ger |
dc.subject |
Notch-Signalweg |
ger |
dc.subject.ddc |
570 | Biowissenschaften, Biologie
|
eng |
dc.title |
Transcriptional regulation of smooth muscle cell differentiation in the murine ureter |
eng |
dc.type |
DoctoralThesis |
eng |
dc.type |
Text |
eng |
dcterms.extent |
vii, 189 S. |
|
dc.description.version |
publishedVersion |
eng |
tib.accessRights |
frei zug�nglich |
eng |