- Home
- →
- Fakultäten
- →
- Naturwissenschaftliche Fakultät
- →
- View Item
Download statistics - Document (COUNTER):
Lercher, L.; Danilenko, N.; Kirkpatrick, J.; Carlomagno, T.: Structural characterization of the Asf1-Rtt109 interaction and its role in histone acetylation. In: Nucleic Acids Research 46 (2018), Nr. 5, S. 2279-2289. DOI: https://doi.org/10.1093/nar/gkx1283
Repository version
Selected time period:
Sum total of downloads: 93
| Abstract: | |
Acetylation of histone H3 at lysine-56 by the histone acetyltransferase Rtt109 in lower eukaryotes is important for maintaining genomic integrity and is required for C. albicans pathogenicity. Rtt109 is activated by association with two different histone chaperones, Vps75 and Asf1, through an unknown mechanism. Here, we reveal that the Rtt109 C-terminus interacts directly with Asf1 and elucidate the structural basis of this interaction. In addition, we find that the H3 N-terminus can interact via the same interface on Asf1, leading to a competition between the two interaction partners. This, together with the recruitment and position of the substrate, provides an explanation of the role of the Rtt109 C-terminus in Asf1-dependent Rtt109 activation. | |
| License of this version: | CC BY-NC 4.0 Unported |
| Document Type: | Article |
| Publishing status: | publishedVersion |
| Issue Date: | 2018 |
| Appears in Collections: | Naturwissenschaftliche Fakultät |
distribution of downloads over the selected time period:
downloads by country:
| pos. | country | downloads | ||
|---|---|---|---|---|
| total | perc. | |||
| 1 |  |
Germany | 50 | 53.76% |
| 2 |  |
United States | 19 | 20.43% |
| 3 |  |
Russian Federation | 5 | 5.38% |
| 4 |  |
China | 5 | 5.38% |
| 5 |  |
Indonesia | 4 | 4.30% |
| 6 |  |
Czech Republic | 4 | 4.30% |
| 7 |  |
United Kingdom | 2 | 2.15% |
| 8 |  |
Japan | 1 | 1.08% |
| 9 |  |
Italy | 1 | 1.08% |
| 10 |  |
France | 1 | 1.08% |
| other countries | 1 | 1.08% | ||
Further download figures and rankings:
Hinweis
Zur Erhebung der Downloadstatistiken kommen entsprechend dem „COUNTER Code of Practice for e-Resources“ international anerkannte Regeln und Normen zur Anwendung. COUNTER ist eine internationale Non-Profit-Organisation, in der Bibliotheksverbände, Datenbankanbieter und Verlage gemeinsam an Standards zur Erhebung, Speicherung und Verarbeitung von Nutzungsdaten elektronischer Ressourcen arbeiten, welche so Objektivität und Vergleichbarkeit gewährleisten sollen. Es werden hierbei ausschließlich Zugriffe auf die entsprechenden Volltexte ausgewertet, keine Aufrufe der Website an sich.