Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa

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Heinemann, H.; Becker, K.; Schrey, H.; Zeng, H.; Stadler, M. et al.: Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa. In: RSC Advances 42 (2023), S. 29768-29772. DOI: https://doi.org/10.1039/D3RA06542A

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Abstract: 
Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
License of this version: CC BY 3.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2023
Appears in Collections:Naturwissenschaftliche Fakultät
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1 image of flag of Germany Germany 17 60.71%
2 image of flag of United States United States 8 28.57%
3 image of flag of China China 2 7.14%
4 image of flag of Indonesia Indonesia 1 3.57%
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