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Download statistics - Document (COUNTER):
Kuca, K.; Musilova, L.; Palecek, J.; Cirkva, V.; Paar, M. et al.: Novel bisquaternary oximes - Reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. In: Molecules 14 (2009), Nr. 12, S. 4915-4921. DOI: https://doi.org/10.3390/molecules14124915
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Sum total of downloads: 112
| Abstract: | |
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AchE; EC 3.1.1.7) and butyryl-cholinesterase (BuChE; EC 3.1.1.8) inhibited by paraoxon. Their reactivation activity was compared with standard reactivators - pralidoxime, obidoxime and HI-6 - which are clinically used at present. As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. In case of BuChE reactivation, two compounds (K053 and K068) achieved similar results as obidoxime. | |
| License of this version: | CC BY-NC-SA 3.0 Unported |
| Document Type: | Article |
| Publishing status: | publishedVersion |
| Issue Date: | 2009 |
| Appears in Collections: | Naturwissenschaftliche Fakultät |
distribution of downloads over the selected time period:
downloads by country:
| pos. | country | downloads | ||
|---|---|---|---|---|
| total | perc. | |||
| 1 |  |
Germany | 66 | 58.93% |
| 2 |  |
United States | 24 | 21.43% |
| 3 |  |
China | 8 | 7.14% |
| 4 |  |
Poland | 2 | 1.79% |
| 5 |  |
France | 2 | 1.79% |
| 6 |  |
Canada | 2 | 1.79% |
| 7 |  |
Netherlands | 1 | 0.89% |
| 8 |  |
Korea, Republic of | 1 | 0.89% |
| 9 |  |
Kenya | 1 | 0.89% |
| 10 |  |
Indonesia | 1 | 0.89% |
| other countries | 4 | 3.57% | ||
Further download figures and rankings:
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