Alekseychuk, M.; Heretsch, P.: Biogenetic space-guided synthesis of rearranged terpenoids. In: Chemical Communications : ChemComm 59 (2023), Nr. 45, S. 6811-6826. DOI: https://doi.org/10.1039/d3cc01009k
Abstract: | |
Natural product chemistry is constantly challenged by newly discovered, complex molecules. Elements of complexity arise from unprecedented frameworks, with a large amount of densely packed stereogenic centres and different functional groups along with a generally high oxidation state. As a prime example, rearranged triterpenoids possess all these elements. For their total synthesis, a limit of what is considered sensible in terms of steps and yield is frequently reached. As an alternative, semisynthetic approaches have gained a great amount of attention in recent years. In this featured article, we present our and others' contributions towards the development of efficient and economic syntheses of complex terpenoid natural products and elaborate on the underlying rationale of biogenetic space-guided synthetic analysis. | |
License of this version: | CC BY 3.0 Unported |
Document Type: | Article |
Publishing status: | publishedVersion |
Issue Date: | 2023 |
Appears in Collections: | Naturwissenschaftliche Fakultät |
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