Digitization is constantly affecting the working world and is of enormous interest in many fields of science. But to what extent are innovative technologies actually being applied in regional SMEs and what are the obstacles to their introduction? From a psychological point of view, it is essential to consider the employee's health and the effects of innovative technologies on their everyday work. The aim of using innovative technologies should not be to completely replace human labor or to dequalify employees, but to relieve the workforce and free up working time for more meaningful activities. One concept that should be included in the human-centered design of human-machine interaction in artificial intelligence is the HAI-MMI concept (Huchler, 2020), which offers starting points for high-quality collaboration at various levels.To reduce the gap between science and industry, this paper focuses on the actual demands of SME in the Aachen region in Germany referring to a requirements analysis within the research project AKzentE4.0 (N = 50 SME) and discusses how appropriate innovative technologies of the Industry 4.0 and AI can be implemented and deployed in a human-centred way. Moreover, the establishment of a Human Factors Competence Center for Employment in Industry 4.0 is outlined, which is meant to be used for the dissemination of research results from the project and should narrow the gap between science and industry in the long run.