The challenges for industrial companies in the area of factory planning and operation are characterised on the one hand by permanently shortening product life cycles and increasing product diversity. Furthermore, the demand for ecologically sustainable processes is growing and the complexity of production systems is increasing due to higher product complexity. This results in a complex decision-making space for companies within factory planning and factory operation which is difficult to plan. The advancing digitalisation can bring a great opportunity here. Modelling and simulation can create greater transparency in the context of planning and operation, and processes can be designed to be ecologically sustainable and efficient. Currently, research approaches in the context of factory planning and operation are focussing on the application and use of digital methods and tools of the Digital Factory (DF). However, the application is limited to individual areas in factory planning or factory operation.For this reason, this paper focuses on the design of a framework that addresses both factory planning and factory operation aspects and links them through modelling and simulation. Cyber-physical production systems (CPPS) can help here by mapping the individual modules within planning and operation using individual agents in agent-based simulation (AB). By linking planning and real data, the processes from planning and operation can be taken into account. From this, insights gained from planning can be simulated in an early phase and subjected to optimisation during operation. The cycle-oriented CPPS can be used on an ongoing basis by preparing the generic building blocks on the planning and operational sides through structured data acquisition and implementing them in the real world with the help of decision support from the virtual world.