Browsing by Subject "steric exclusion chromatography"

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Downstream processing of lentiviral vectors with focus on steric exclusion chromatography

Labisch, Jennifer Julia (Hannover : Institutionelles Repositorium der Leibniz Unversität Hannover, 2023)

Lentiviral vectors (LV) are widely used to deliver therapeutic genes for gene therapy and gene-modified cell therapy and have shown success in chimeric antigen T cell therapies. The ongoing market growth leads to an ...
Scaling Up of Steric Exclusion Membrane Chromatography for Lentiviral Vector Purification

Labisch, Jennifer Julia; Paul, Richard; Wiese, G. Philip; Pflanz, Karl (Basel : MDPI, 2023)

Lentiviral vectors (LVs) are widely used in clinical trials of gene and cell therapy. Low LV stability incentivizes constant development and the improvement of gentle process steps. Steric exclusion chromatography (SXC) ...
Steric Exclusion Chromatography for Purification of Biomolecules—A Review

Labisch, Jennifer J.; Wiese, G. Philip; Pflanz, Karl (Basel : MDPI, 2023)

Steric exclusion chromatography (SXC) is a purification method that is based on steric exclusion effects from the surface of the target and a hydrophilic stationary phase after the addition of polyethylene glycol (PEG), ...

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