Browsing by Subject "Virulence factors"

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Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species

Trottmann, Felix; Franke, Jakob; Richter, Ingrid; Ishida, Keishi; Cyrulies, Michael; Dahse, Hans-Martin; Regestein, Lars; Hertweck, Christian (Weinheim : Wiley-VCH Verlag, 2019)

Burkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While ...
Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor

Trottmann, Felix; Ishida, Keishi; Franke, Jakob; Stanišić, Aleksa; Ishida-Ito, Mie; Kries, Hajo; Pohnert, Georg; Hertweck, Christian (Weinheim : Wiley-VCH, 2020)

Pathogenic bacteria of the Burkholderia pseudomallei group cause severe infectious diseases such as glanders and melioidosis. Malleicyprols were identified as important bacterial virulence factors, yet the biosynthetic ...

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