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Application of an online-biomass sensor in an optical multisensory platform prototype for growth monitoring of biotechnical relevant microorganism and cell lines in single-use shake flasks

Ude, Christian; Schmidt-Hager, Jörg; Findeis, Michael; John, Gernot Thomas; Scheper, Thomas; Beutel, Sascha (Basel : MDPI AG, 2014)

In the context of this work we evaluated a multisensory, noninvasive prototype platform for shake flask cultivations by monitoring three basic parameters (pH, pO2 and biomass). The focus lies on the evaluation of the biomass ...
Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Lederle, Mario; Tric, Mircea; Roth, Tatjana; Schütte, Lina; Rattenholl, Anke; Lütkemeyer, Dirk; Wölfl, Stefan; Werner, Tobias; Wiedemann, Philipp (Weinheim : Wiley-VCH, 2021)

Great efforts are directed towards improving productivity, consistency and quality of biopharmaceutical processes and products. One particular area is the development of new sensors for continuous monitoring of critical ...
Three-dimensional cell growth on structures fabricated from ORMOCER® by two-photon polymerization technique

Schlie, Sabrina; Ngezahayo, Anaclet; Ovsianikov, Aleksandr; Fabian, Tilman; Kolb, Hans-Albert; Haferkamp, Heinz; Chichkov, Boris (London : SAGE Publications Ltd., 2007)

Two-photon polymerization technique was applied to generate three-dimensional (3D) scaffold-like structures using the photosensitive organic-inorganic hybrid polymer ORMOCER®. The structures were studied with respect to ...

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