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Browsing by Author "101f5cc8-e27d-4b3e-a59e-769267a3cf8a"

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Automation of cell culture assays using a 3D-printed servomotor-controlled microfluidic valve system

Winkler, Steffen; Menke, Jannik; Meyer, Katharina V.; Kortmann, Carlotta; Bahnemann, Janina (Cambridge : RSC, 2022)

Microfluidic valve systems show great potential to automate mixing, dilution, and time-resolved reagent supply within biochemical assays and novel on-chip cell culture systems. However, most of these systems require a ...
Development of Aptamer-Based TID Assays Using Thermophoresis and Microarrays

Kurth, Tracy; Witt, Sandra; Bolten, Svenja; Waniek, Janice-Joy; Kortmann, Carlotta; Lavrentieva, Antonina; Scheper, Thomas; Walter, Johanna-Gabriela (Basel : MDPI AG, 2019)

Aptamers are single-stranded oligonucleotides which can be used as alternative recognition elements for protein detection, because aptamers bind their targets with a high affinity similar to antibodies. Due to the ...
Employing QbD strategies to assess the impact of cell viability and density on the primary recovery of monoclonal antibodies

Wohlenberg, Ole Jacob; Kortmann, Carlotta; Meyer, Katharina V.; Scheper, Thomas; Solle, Dörte (Weinheim : Wiley-VCH, 2023)

Quality by Design (QbD) is one of the most important tools for the implementation of Process Analytical Technology (PAT) in biopharmaceutical production. For optimal characterization of a monoclonal antibody (mAb) upstream ...
In vitro biocompatibility evaluation of a heat-resistant 3D printing material for use in customized cell culture devices

Winkler, Steffen; Meyer, Katharina V.; Heuer, Christopher; Kortmann, Carlotta; Dehne, Michaela; Bahnemann, Janina (Weinheim : Wiley-VCH, 2022)

Additive manufacturing (3D printing) enables the fabrication of highly customized and complex devices and is therefore increasingly used in the field of life sciences and biotechnology. However, the application of 3D-printed ...
Optimization of a mAb production process with regard to robustness and product quality using quality by design principles

Wohlenberg, Ole Jacob; Kortmann, Carlotta; Meyer, Katharina V.; Schellenberg, Jana; Dahlmann, Katharina; Bahnemann, Janina; Scheper, Thomas; Solle, Dörte (Weinheim : Wiley-VCH, 2022)

Quality by Design principles are well described and widely used in biopharmaceutical industry. The characterization of a monoclonal antibody (mAb) production process is crucial for novel process development and control. ...

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Browsing by Author "101f5cc8-e27d-4b3e-a59e-769267a3cf8a"

Browsing by Author "101f5cc8-e27d-4b3e-a59e-769267a3cf8a"

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